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Researchers in US report promising new Alzheimer’s drug
A new experimental treatment against Alzheimer's has proved to be promising and free of harmful side effects, researchers in the United States reported Wednesday.
The research published in the journal Science Translational Medicine on the basis of a small 32-person sample gave rise to two broader clinical trials that are now underway with more than 3,000 subjects.
The treatment uses a compound called
In people with Alzheimer’s disease, the proteins clump into plaques that damage the brain, affecting cognitive abilities, especially memory. The enzyme plays a key role in production of the proteins.
The 32 people who participated in the first clinical trial had been diagnosed with mild to moderate Alzheimer’s.
Pharmaceutical labs are working to develop compounds that can stop or even reverse the formation of these plaques.
Until now, products developed to neutralize the BACEI enzyme had very toxic side effects, such as liver damage or further neuro-degeneration.
But
Researchers found that one or two doses of the compound were enough to lower protein levels without causing side effects.
The two so-called phase 3 clinical trials now under way to evaluate how well
If the results are good, the compound could be marketed as a pill in two or three years.
The number of people in the United States suffering from mind-wasting Alzheimer’s could surpass 28 million by 2050 after the entire baby boomer generation gets past age 80, according to projections.
The World Health Organization says 36 million people around the world suffer from some form of dementia, most of them with Alzheimer.
The figure is expected to double by 2030 to exceed 65.7 million, and triple by 2050 to 115.4 million, if no effective treatment is found in the next few years.
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